A Three-component Cascade Cyclization to Construct 3-(2-Oxopropyl)-2-arylisoindolinone Derivatives via Copper-catalyzed Annulation was written by Liu, Li;Bai, Shu-Hua;Li, Yang;Ding, Xiao-Dan;Liu, Qian;Li, Jian. And the article was included in Advanced Synthesis & Catalysis in 2018.Formula: C19H22F3IO3S The following contents are mentioned in the article:
In the presence of Cu(OTf)2, o-formylbenzonitriles, ketones such as acetophenone, and diaryliodonium triflates such as (4-BrC6H4)2I+OTf– underwent cascade arylation, cyclization and addition reactions in 1,2-dichloroethane to yield (oxoalkyl)arylisoindolinones such as I in 51-90% yields; α-methylstyrene and di-Et malonate were also used instead of ketones to yield a propenylisoindolinone and an aryloxoisoindolylmalonate, resp. Copper-catalyzed arylation, cyclization and addition followed by ketone reduction and Friedel-Crafts reactions yielded isoindoloquinolinones such as II. This study involved multiple reactions and reactants, such as Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3Formula: C19H22F3IO3S).
Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Formula: C19H22F3IO3S
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com