Copper-catalyzed enantioselective arylalkynylation of alkenes was written by Lei, Guangyue;Zhang, Hanwen;Chen, Bin;Xu, Meichen;Zhang, Guozhu. And the article was included in Chemical Science in 2020.Category: iodides-buliding-blocks The following contents are mentioned in the article:
A copper-catalyzed enantioselective arylalkynation of alkenes, e.g., p-methylstyrene, with a diaryliodonium salt, e.g., diphenyliodonium hexafluorophosphate, and monosubstituted alkynes RCCH (R = Ph, cyclopropyl, thiophen-3-yl, etc.) is reported. The three-component coupling reactions proceed under mild reaction conditions with a broad substrate scope, leading to synthetically valuable 1,2-diaryl-3-butynes, e.g., (R)-[3-(p-tolyl)but-1-yne-1,4-diyl]dibenzene. The key to the success of this chem. is the employment of chiral bisoxazoline-phenylaniline (BOPA) ligand I. A novel reaction pathway involving Ph radical generation under thermal copper catalysis is proposed according to mechanistic studies. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Category: iodides-buliding-blocks).
Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Category: iodides-buliding-blocks
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com