Tang, Guozhi et al. published their research in Journal of Medicinal Chemistry in 2014 | CAS: 371764-70-4

2-Chloro-4-iodobenzonitrile (cas: 371764-70-4) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Electric Literature of C7H3ClIN

Identification of a Novel Aminotetralin Class of HDAC6 and HDAC8 Selective Inhibitors was written by Tang, Guozhi;Wong, Jason C.;Zhang, Weixing;Wang, Zhanguo;Zhang, Nan;Peng, Zhenghong;Zhang, Zhenshan;Rong, Yiping;Li, Shijie;Zhang, Meifang;Yu, Lingjie;Feng, Teng;Zhang, Xiongwen;Wu, Xihan;Wu, Jim Z.;Chen, Li. And the article was included in Journal of Medicinal Chemistry in 2014.Electric Literature of C7H3ClIN The following contents are mentioned in the article:

Herein we report the identification of a novel class of HDAC6 and HDAC8 selective inhibitors through a unique chem. and phenotypic screening strategy. Tetrahydroisoquinoline 12 was identified as a potent HDAC6 and HDAC8 dual inhibitor from a focused library through cellular tubulin acetylation and p21 induction screening assays. Scaffold hopping from 12 led to the discovery of an aminotetralin class of HDAC inhibitors. In particular, the 3-R stereoisomer 32 showed highly potent inhibition against HDAC6 and HDAC8 with IC50 values of 50 and 80 nM, resp. Treatment of neuroblastoma BE(2)C cells with 32 resulted in elevated levels of acetylated tubulin, TrkA, and neurite outgrowth with only marginal effects on p21 induction and histone H3 acetylation. Consistent with its weak enzymic inhibition of HDAC1, 32 showed significantly less cytotoxicity than SAHA and moderately inhibited the growth of myeloma NCI-H929 and OPM-2 cells. This study involved multiple reactions and reactants, such as 2-Chloro-4-iodobenzonitrile (cas: 371764-70-4Electric Literature of C7H3ClIN).

2-Chloro-4-iodobenzonitrile (cas: 371764-70-4) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Electric Literature of C7H3ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com