One-Pot C-H Arylation/Lactamization Cascade Reaction of Free Benzylamines was written by Chand-Thakuri, Pratibha;Landge, Vinod G.;Kapoor, Mohit;Young, Michael C.. And the article was included in Journal of Organic Chemistry in 2020.Electric Literature of C9H8ClIO2 The following contents are mentioned in the article:
An efficient method was developed for the synthesis of seven-membered biaryl lactams I [R1 = H, 8-F, 9-OMe, etc.; R2 = R3 = H, Me; R2 = H, R3 = Me; R2 = Me, R3 = Et, n-Pr, n-Bu, etc.; R4 = H, 2-Cl, 3-I, etc.] involving Pd-catalyzed, native amine-directed, ortho-arylation of benzylamines followed by in situ lactamization. This cascade sequence was enabled by the use of 2-iodobenzoates, which facilitated C-H arylation from the free amine under conditions that typically required an improved directing group approach. This reaction was characterized by a broad substrate scope with good functional group tolerance. The need for an ester vs. carboxylic acid-functionalized coupling partner was also explored, as the potential for synthesizing eight-membered biaryl lactams. Various applications were also investigated, including access to the aza-Brassinolide core. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4Electric Literature of C9H8ClIO2).
Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Electric Literature of C9H8ClIO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com