Efficient N-arylation of azole compounds utilizing selective aryl-transfer TMP-iodonium(III) reagents was written by Koseki, Daichi;Aoto, Erika;Shoji, Toshitaka;Watanabe, Kazuma;In, Yasuko;Kita, Yasuyuki;Dohi, Toshifumi. And the article was included in Tetrahedron Letters in 2019.Product Details of 1204518-02-4 The following contents are mentioned in the article:
It was determined that diaryliodonium(III) triflates bearing a trimethoxybenzene (TMP) auxiliary 2,4,6-(OCH3)3C6H2I+Ar-OTf– (Ar = Ph, 4-methylphenyl, 4-methoxyphenyl, 2-chlorophenyl, thiophene-3-yl) are more reactive than the reported selective aryl-transfer iodonium salts in the N-arylation of benzimidazoles I (R = H, 5-NO2, 6-Me, 5-OMe, 5-C(O)OMe) and other types of azole compounds such as 1H-imidazole, 2-methyl-1H-imidazole and 1H-pyrazole under catalytic conditions. The TMP-iodonium(III) salts can thus effectively facilitate the reaction at 50 °C or below, producing the corresponding N-arylated biaryls, e.g., II without the formation of TMP-derived coupling byproducts. Utilization of this TMP reagent under mild conditions would prevent the underlying problem of participation of the auxiliary group in the coupling reactions, which are observed while using the iodonium(III) salts that require elevated temperatures This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Product Details of 1204518-02-4).
Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Product Details of 1204518-02-4
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com