Substitution products of 4-nitro- and 4-acetamidodiphenyl ether was written by Scarborough, Harold A.. And the article was included in Journal of the Chemical Society in 1929.Name: 1-Iodo-4-(4-nitrophenoxy)benzene The following contents are mentioned in the article:
4-ClC6H4OC6H4NO2-4 (I), m. 76°, results from 4-O2NC6H4OPh (II) and Cl in AcOH or from p-O2NC6H4Cl and p-ClC6H4OK; the 4-Br derivative (III), m. 61°, was prepd, similarly. 4-NO2CdH4OPh and ICl in AcOH give 4-iodo-4′-nitrodiphenyl ether (IV), pale yellow, m. 71°; Cl precipitates a stable iodochloride, yellow. II or III in dry Br or p-ClC6H4NO2 and 2,4-Br2C6H3OK give 2,4-dibromo-4′-nitrodiphenyl ether, m. 81°. Reduction of II in EtOH- or Et2O-HCl with SnCl2 gives 4-aminodiphenyl ether-HCl, m. 238°; the Ac derivative, m. 127°. Reduction of I gives the NH2 derivative, m. 101°, whose Ac derivative (V), m. 146°. Nitration of V gives the 3-NO2 derivative, yellow, m. 98°; hydrolysis gives 4′-chloro-3-nitro-4-aminodiphenyl ether, m. 114°; deamination gives 4′-chloro-3-nitrodiphenyl ether, yellow, m. 60°. 4-Bromo-4′-acetaminodiphenyl ether, m. 161°; nitration gives 4′-bromo-3-nitro-4-acetaminodiphenyl ether, yellow, m. 107°; hydrolysis gives the free NH2 derivative, scarlet, m. 144°; deamination gives 4′-bromo-3-nitrodiphenyl ether, yellow, m. 64°. 4-Iodo-4′-aminodiphenyl ether, m. 91°; Ac deriv; m. 174°. 4′-Iodo-3-nitro-4-acetaminodiphenyl ether, yellow, m. 123°; hydrolysis gives the free NH2 derivative, scarlet, m. 155°. 3-Nitro-4-aminodiphenyl ether, bright red, m. 82°; Ac derivative, deep yellow, m. 100°. 2,4-Dibromo-4′-acetaminodiphenyl ether, m. 158°; 3′-NO2 derivative, yellow, m. 141°; the free NH2 derivative, yellow, m. 107°; deamination gives 2,4-dibromo-3′-nitrodiphenyl ether, orange, m. 72°. 4-Iododiphenyl ether, m. 48°; dichloride, yellow. 4-Bromo-4′-iododiphenyl ether, m. 72°. 4,4′-Diiododiphenyl ether, m. 139°. This study involved multiple reactions and reactants, such as 1-Iodo-4-(4-nitrophenoxy)benzene (cas: 21969-05-1Name: 1-Iodo-4-(4-nitrophenoxy)benzene).
1-Iodo-4-(4-nitrophenoxy)benzene (cas: 21969-05-1) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Name: 1-Iodo-4-(4-nitrophenoxy)benzene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com