Klopman, Gilles published the artcileComputer-aided study of the relationship between structure and antituberculosis activity of a series of isoniazid derivatives, Quality Control of 39115-95-2, the publication is Chemical Physics (1996), 204(2,3), 181-93, database is CAplus.
The Multiple Computer Automated Structure Evaluation (MultiCASE) program was used to analyze the relation between the structure and antituberculous activity of a series of 136 hydrazides, most of them isoniazid related. The structural features revealed by this anal. are discussed. The most significant one seemed to be the distance between the pyridinic nitrogen and the terminal nitrogen of the hydrazido group. Given the affiliation of these two heteroatoms with a planar conjugated system, we suggest that Schiff base chem. similar to that of vitamin B6 may be involved in the mode of action of isoniazid and its related compounds A mechanism of action of isoniazid is proposed and suggestions for the design of new isoniazid-type drugs are made.
Chemical Physics published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com