Wang, Xiu’s team published research in Research on Chemical Intermediates in 47 | CAS: 39115-95-2

Research on Chemical Intermediates published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C10H9ClN2O, Application In Synthesis of 39115-95-2.

Wang, Xiu published the artcileSynthesis, antifungal activity and 3D-QSAR study of novel nopol-based 1,3,4-thiadiazole-thioether compounds, Application In Synthesis of 39115-95-2, the publication is Research on Chemical Intermediates (2021), 47(10), 4029-4049, database is CAplus.

A series of novel nopol derivatives containing 1,3,4-thiadiazole-thioether moiety I [R = H, 2-Me, 3-CF3, etc.] were synthesized from β-pinene, which is a natural, abundant and renewable biomass resource. Their structures were characterized by FT-IR, 1H NMR, 13C NMR, ESI-MS and elemental anal. In vitro antifungal activity of the target compounds was preliminarily evaluated against eight tested plant pathogens, including Fusarium oxysporum f. sp. cucumerinum, Cercospora arachidicola, Physalospora piricola, Alternaria solani, Gibberella zeae, Rhizoeotnia solani, Bipolaris maydis and Colleterichum orbicalare. The bioassay results revealed that, at the concentration of 50μg/mL, all the target compounds showed certain inhibition activity against the eight tested fungi. Compounds I [R = 3-OMe, 3-F, 3-I] had excellent inhibition rates of 77.8%, 88.9% and 77.8%, resp., against P. piricola, showing much better antifungal activity than that of the pos. control chlorothalonil. Meanwhile, compound I [R = 4-Cl] displayed antifungal activity of 80.7% against R. solani. Furthermore, the anal. of three-dimensional quant. structure-activity relationship (3D-QSAR) was performed for the relationship between the structures of the target compounds and their antifungal activity against P. piricola by CoMFA method. A reasonable CoMFA model (n = 6; q2 = 0.597; r2 = 0.985) was established.

Research on Chemical Intermediates published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C10H9ClN2O, Application In Synthesis of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com