Munchhof, Michael J. published the artcileDesign and SAR of thienopyrimidine and thienopyridine inhibitors of VEGFR-2 kinase activity, Related Products of iodides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2004), 14(1), 21-24, database is CAplus and MEDLINE.
Novel classes of thienopyrimidines and thienopyridines have been identified as potent inhibitors of VEGFR-2 kinase. The synthesis and structure-activity relationship of these compounds is presented, along with successful efforts to diminish EGFR activity present in the lead series. The presence of a 2-Me substituent in the indole moiety in the [(2-methyl-1H-indol-5-yl)amino]thieno[3,2-b]pyridine series [I, R = CH2N(Me)(CH2)2OH, CH2NH(CH2)3OH, CH2NH(CH2)2O(CH2)2OH, CH2NH(CH2)2OH, etc., R1 = Me] was found to decrease EGFR activity more than 100-fold, while having little effect on VEGFR activity, when compared to [(1H-indol-5-yl)amino]thieno[3,2-b]pyridines I (same R, R1 = H).
Bioorganic & Medicinal Chemistry Letters published new progress about 602303-26-4. 602303-26-4 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 7-Chloro-2-iodothieno[3,2-b]pyridine, and the molecular formula is C7H3ClINS, Related Products of iodides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com