Tseng, Chih-Chung published the artcileThe Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators, HPLC of Formula: 101420-79-5, the publication is Journal of Medicinal Chemistry (2019), 62(10), 5049-5062, database is CAplus and MEDLINE.
3-Nitroalkyl-2-phenylindoles were prepared as analogs of known CB1 receptor pos. allosteric modulators; related 3-(trifluoroalkyl)-2-phenylindoles such as I were prepared to test if the trifluoromethyl group could act as a bioisostere of the nitro group. The trifluoromethyl-bearing compounds were generally more potent than their nitro equivalent and also showed improved in vitro metabolic stability. The racemate of I has similar activity to the known CB1 receptor pos. allosteric modulator (±)-ZCZ011, with both showing promising efficacy in a mouse model of neuropathic pain.
Journal of Medicinal Chemistry published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C6H8O4, HPLC of Formula: 101420-79-5.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com