Li, Yibiao published the artcileAccess to 2-pyridinylamide and imidazopyridine from 2-fluoropyridine and amidine hydrochloride, Computed Properties of 153034-78-7, the main research area is pyridinylamide preparation; fluoropyridine amidation amidine hydrochloride chemoselective; imidazopyridine preparation chemoselective regioselective.
Under catalyst-free conditions, an efficient method to synthesize 2-pyridinylamides has been developed, and the protocol uses inexpensive and readily available 2-fluoropyridines and amidine derivatives as the starting materials. Simultaneously, the copper-catalyzed approach to imidazopyridine derivatives has been established with high chemoselectivity and regiospecificity. The results suggest that the nitrogen-heterocycles containing iodide substituents can also be compatible for the reaction via the cascade Ullmann-type coupling, and the nucleophilic substitution reaction provides the target products in a one-pot manner.
Organic & Biomolecular Chemistry published new progress about Amidation. 153034-78-7 belongs to class iodides-buliding-blocks, name is 2-Fluoro-3-iodo-5-methylpyridine, and the molecular formula is C6H5FIN, Computed Properties of 153034-78-7.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com