Chen, Rongxiang published the artcileIn situ generation of nitrile oxides from copper carbene and tert-butyl nitrite: synthesis of fully substituted isoxazoles, COA of Formula: C11H11IO3, the main research area is keto ester diazoacetate cycloaddition copper nitrite; isoxazole preparation; nitrile oxide in situ copper carbene nitrite.
A [3 + 2] cycloaddition reaction of β-keto esters with nitrile oxides, which were generated in situ from copper carbene and tert-Bu nitrite, is reported. This three-component reaction provides methodol. for the direct synthesis of fully substituted isoxazole derivatives, featuring mild reaction conditions, readily accessible starting materials and simple operation. The exptl. studies and DFT calculations suggest that the reaction starts with the generation of the key intermediate nitrile oxides, followed by a [3 + 2] cycloaddition reaction of β-keto esters to give the final isoxazole products.
Organic & Biomolecular Chemistry published new progress about [3+2] Cycloaddition reaction. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, COA of Formula: C11H11IO3.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com