Gundoju, Narayanarao published the artcileBetulinic acid derivatives: a new class of α-glucosidase inhibitors and LPS-stimulated nitric oxide production inhibition on mouse macrophage RAW 264.7 cells, Name: 4-Iodo-3-nitroaniline, the main research area is betulinic acid alpha glucosidase inhibitor; LPS-stimulated nitric oxide production inhibition; betulinic acid; α-glucosidase inhibition.
Chem. manipulation studies were conducted on betulinic acid, twenty-one new rationally designed analogs of betulinic acid with modifications at C-28 were synthesized for their evaluation of inhibitory effects on α-glucosidase and LPS-stimulated nitric oxide production in mouse macrophage RAW 264.7 cells. 2-Oxo-2-morpholinoethyl 3β-hydroxylup-20(29)-en-28-oate (2; IC50 = 5.4 μM) exhibited an almost 1.4-fold increase in α-glucosidase inhibitory activity on yeast α-glucosidase while analogs (IC50 16.4 μM) and (IC50 16.6 μM) exhibited a 2-fold enhanced inhibitory activity on NO-production than betulinic acid.
Natural Product Research published new progress about Structure-activity relationship. 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Name: 4-Iodo-3-nitroaniline.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com