On October 15, 2015, Loso, Michael R.; Gustafson, Gary D.; Kubota, Asako; Yap, Maurice C.; Buchan, Zachary A.; Steward, Kimberly M.; Sullenberger, Michael T.; Hoekstra, William J.; Yates, Christopher M. published a patent.COA of Formula: C7H3BrF3I The title of the patent was Preparation of metalloenzyme inhibitor compounds as fungicides for pharmaceutical and agricultural use. And the patent contained the following:
The invention describes compounds of formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes as well the use of I to protect and/or cure plants against damage caused by agriculturally relevant fungi. I [wherein Z is (un)substituted pyrimidinyl, thiazolyl, oxazolyl, etc.; R1 is alkyl, haloalkyl, (hetero)aryl, etc.; R2 is aryl or heteroaryl; R3 is H, alkyl, (hetero)aryl, etc.; R4, R5, R6, and R7 are independently H, alkyl, alkoxy, etc.] are claimed and exemplified. Coupling of 1-(4-bromophenyl)-2,2-dimethyl-1-(pyrimidin-5-yl)propan-1-ol with (4-(trifluoromethoxy)phenyl)boronic acid provided II in 93% yield. Candidate compounds of I were evaluated for fungicidal activity against Leaf Blotch of Wheat (Mycosphaerella graminicola; Anamorph; Septoria tritica; Bayer Code SEPTTR)(data given). The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).COA of Formula: C7H3BrF3I
The Article related to metalloenzyme inhibitor preparation pharmaceutical agricultural fungicide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.COA of Formula: C7H3BrF3I
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com