On May 6, 2016, Welz, Claudia; Koehler, Adeline; Boerngen, Kirsten; Kulke, Daniel; Goergens, Ulrich; Schwarz, Hans-Georg; Ilg, Kerstin published a patent.Computed Properties of 364-12-5 The title of the patent was Preparation of arylamide compounds for use in anthelmintic treatment. And the patent contained the following:
Disclosed are compounds of formula I which possess anthelmintic properties wherein the structural elements have the meaning as indicated in the description. Further disclosed are such compounds for the control, treatment and/or prevention of infections with helminths in animals and humans. Compounds of formula I wherein n is 1, 2 and 3; m is 0, 1, 2, 3 and 4; R1 is H, CHO, OH, C1-4 alkyl,e tc.; each X is independently halo, NO2, CN, amino, etc.; each Y is independently H, halo, NO2, CN, OH, SH, etc.; A is (un)substituted Ph, (un)substituted pyridinyl and (un)substituted pyrazinyl; and salts, solvates, solvates of salts, N-oxides, metal complexes and metalloid complexes thereof, are claimed. Example compound II was prepared by amidation of 2-trifluoromethylbenzoyl chloride with 2-(4-bromo-2- chloro-phenyl)-2,2-difluoro-ethanamine; the resulting N-[2-(4-bromo-2-chloro-phenyl)-2,2-difluoro-ethyl]-2-(trifluoromethyl)benzamide underwent cross-coupling with 4-fluorophenylboronic acid to give compound II. The invention compounds were evaluated for their anthelmintic activity (some data given). The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Computed Properties of 364-12-5
The Article related to arylamide preparation anthelmintic, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Computed Properties of 364-12-5
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com