Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Related Products of 144-48-9.
Pop, Bianca;Ionut, Ioana;Marc, Gabriel;Vodnar, Dan Cristian;Pirnau, Adrian;Vlase, Laurian;Oniga, Ovidiu research published 《 Development of new 2-methyl-4-salicylamide thiazole derivatives: synthesis, antimicrobial activity evaluation, lipophilicity and molecular docking study》, the research content is summarized as follows. A series of 15 new thiazolyl-salicylamide ethers I [R = acetonyl, 2-ethoxy-2-oxo-Et, 2-(4-bromophenyl)-2-oxo-Et, etc.] were obtained through an alkylation reaction in alk. medium. The compounds were physico-chem. and spectrally characterized. The evaluation of their antimicrobial activity highlighted the antifungal effect of compound I [R = 2-(4-bromophenyl)-2-oxo-ethyl] which was equivalent to that of fluconazole. A mol. docking study revealed the structurally important elements for a better interaction with target lanosterol I4a-fungal demethylase. Given the importance of the lipophilicity for the penetration of biol. membranes of bioactive mols., this was evaluated in-silico.
144-48-9, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.
2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., Related Products of 144-48-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com