In 2022,Zhu, Yu-Rong; Lin, Jin-Hong; Xiao, Ji-Chang published an article in Synlett. The title of the article was 《Triphenylphosphine/1,2-Diiodoethane-Promoted Formylation of Indoles with N,N -Dimethylformamide》.HPLC of Formula: 624-73-7 The author mentioned the following in the article:
A Ph3P/ICH2CH2I-promoted formylation of indoles with DMF under mild conditions was described. A Vilsmeier-type intermediate was readily formed from DMF promoted by the Ph3P/ICH2CH2I system. A one-step formylation process was applied to various electron-rich indoles, but a hydrolysis needs to be carried out as a second step in the case of electron-deficient indoles. Convenient operations make this protocol attractive. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diiodoethane(cas: 624-73-7HPLC of Formula: 624-73-7)
1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.HPLC of Formula: 624-73-7
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com