In 2022,Huang, Yuanjing; Zhang, Jing published an article in Synthesis. The title of the article was 《Potassium tert-Butoxide Facilitated Amination of Carboxylic Acids with N,N-Dimethylformamide》.Computed Properties of C7H5IO2 The author mentioned the following in the article:
A practical and efficient potassium tert-butoxide (KOtBu)-facilitated amination of carboxylic acids with N,N-dimethylamine was described. In the presence of catalytic amount of KOtBu, a variety of aliphatic and aromatic carboxylic acids were transformed to N,N-dimethylamides using DMF as the dimethylamine reagent with the assistance of trimethylacetic anhydride. The applicability of this protocol was demonstrated by late-stage dimethylamidation of complex drug mols. A plausible reaction mechanism involving KOtBu-facilitated in-situ amine generation from formamide decomposition and anhydride-mediated condensation was proposed on the basis of mechanistic investigations. The results came from multiple reactions, including the reaction of 4-Iodobenzoic acid(cas: 619-58-9Computed Properties of C7H5IO2)
4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Computed Properties of C7H5IO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com