In 2017,Zhang, Shuo; Niu, You-Hong; Ye, Xin-Shan published 《General Approach to Five-Membered Nitrogen Heteroaryl C-Glycosides Using a Palladium/Copper Co-Catalyzed C-H Functionalization Strategy》.Organic Letters published the findings.Synthetic Route of C2H4I2 The information in the text is summarized as follows:
A general approach to the synthesis of diverse heteroaryl-C-Δ1,2-glycosides has been developed by employing the Pd(OAc)2/CuI co-catalyzed direct cross-coupling of five-membered nitrogen heterocycles with 1-iodoglycals in a C-H activation manner. Using this method, 27 examples of heteroaryl-C-Δ1,2-glycosides, containing indoles, thiazoles, benzothiazoles, imidazoles, benzimidazoles, and benzoxazoles as aglycons were obtained in 43-99% yield. The results came from multiple reactions, including the reaction of 1,2-Diiodoethane(cas: 624-73-7Synthetic Route of C2H4I2)
1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Synthetic Route of C2H4I2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com