Sasmal, Sheuli; Prakash, Gaurav; Dutta, Uttam; Laskar, Ranjini; Lahiri, Goutam Kumar; Maiti, Debabrata published an article in 2022. The article was titled 《Directing group assisted rhodium catalyzed meta-C-H alkynylation of arenes》, and you may find the article in Chemical Science.HPLC of Formula: 88-67-5 The information in the text is summarized as follows:
Site-selective C-H alkynylation of arenes to produce aryl alkynes is a highly desirable transformation due to the prevalence of aryl alkynes in various natural products, drug mols. and in materials. To ensure site-selective C-H functionalization, directing group (DG) assisted C-H activation has been evolved as a useful synthetic tool. In contrast to DG-assisted ortho-C-H activation, distal meta-C-H activation is highly challenging and has attracted significant attention in recent years. However, developments are majorly focused on Pd-based catalytic systems. In order to diversify the scope of distal meta-C-H functionalization, herein the first Rh(I) catalyzed meta-C-H alkynylation protocol through the inverse Sonogashira coupling reaction is disclosed. The protocol is compatible with various substrate classes which include phenylacetic acids, hydrocinnamic acids, 2-Ph benzoic acids, 2-Ph phenols, benzyl sulfonates and ether-based scaffolds. The post-synthetic modification of meta-alkynylated arenes is also demonstrated through DG-removal as well as functional group interconversion. In the experimental materials used by the author, we found 2-Iodobenzoic acid(cas: 88-67-5HPLC of Formula: 88-67-5)
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.HPLC of Formula: 88-67-5 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com