《Nickel-Catalyzed Formal Aminocarbonylation of Unactivated Alkyl Iodides with Isocyanides》 was published in Organic Letters in 2020. These research results belong to Huang, Wenyi; Wang, Yun; Weng, Yangyang; Shrestha, Mohini; Qu, Jingping; Chen, Yifeng. Name: tert-Butyl 4-iodopiperidine-1-carboxylate The article mentions the following:
Herein, disclosed a Ni-catalyzed formal aminocarbonylation of primary and secondary unactivated aliphatic iodides with isocyanides to afford alkyl amide, e.g., I, which proceeded via the selective monomigratory insertion of isocyanides with alkyl iodides, subsequent β-hydride elimination, and hydrolysis process. The reaction featured wide functional group tolerance under mild conditions. Addnl., the selective, one-pot hydrolysis of reaction mixture under acid conditions allowed for expedient synthesis of the corresponding alkyl carboxylic acid. The experimental process involved the reaction of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Name: tert-Butyl 4-iodopiperidine-1-carboxylate)
tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Name: tert-Butyl 4-iodopiperidine-1-carboxylate
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com