Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 181765-85-5, name is Methyl 4-chloro-2-iodobenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: 181765-85-5
Synthesized in an analogous manner to Intermediate 143a using Intermediate 033a (0.080 g, 0.195 mmol) and methyl 4-chloro-2-iodobenzoate (0.0694 g, 0.234 mmol) to yield Intermediate 145a (0.050 g, 0.110 mmol, 57% yield): LC-MS (Method A2) RT = 0.93 min, MS (ESI) m/z: 453.1 (M+H)+. 1H NMR (400MHz, CDCl3) delta 7.80 (d, 7=8.4 Hz, 1H), 7.39 (dd, 7=8.4, 2.2 Hz, 1H), 7.33 (d, 7=2.0 Hz, 1H), 7.29 – 7.24 (m, 2H), 7.21 – 7.16 (m, 2H), 4.73 (s, 2H), 3.63 (s, 3H), 2.37 – 2.29 (m, 2H), 2.06 – 1.91 (m, 6H), 1.88 – 1.77 (m, 2H), 1.65 – 1.54 (m, 2H), 1.34 (dq, 7=14.9, 7.4 Hz, 2H), 0.88 (t, 7=7.4 Hz, 3H).
The synthetic route of 181765-85-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSITE DE MONTREAL; BRISTOL-MYERS SQUIBB COMPANY; PRIESTLEY, Eldon, Scott; REZNIK, Samuel, Kaye; RUEDIGER, Edward, H.; GILLARD, James, R.; HALPERN, Oz, Scott; JIANG, Wen; RICHTER, Jeremy; RUEL, Rejean; TRIPATHY, Sasmita; YANG, Wu; ZHANG, Xiaojun; (642 pag.)WO2018/5591; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com