Application of 13421-13-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13421-13-1 as follows.
A solution of 4-chloro-2-iodobenzoic acid 1 (25 g, 88.7 mmol), SOC12 [(100ML),] and DMF (few drops) was warmed gently with a heat gun until the mixture became homogeneous (15 mins). The solution was maintained at [23C] for an additional 30 mins, then the solution was concentrated. [MEOH] (200 mL) was added to the crude residue and the solution was maintained at [23C] for 30 mins. The solution was concentrated and the crude residue was then dissolved in 10: 1 hexanes: EtOAc and passed through a plug of silica gel. The eluent was concentrated to provide 26.2 g (100%) of ester 2 as a colorless oil, which solidified upon standing under high vacuum (0.1 Torr).
According to the analysis of related databases, 13421-13-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CYTOKINETICS, INC.; SMITHKLINE BEECHAM CORPORATION; WO2003/106426; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com