SDS of cas: 63069-48-7In 2021 ,《Palladium-catalyzed carbonylative synthesis of quinazolines: Silane act as better nucleophile than amidine》 appeared in Molecular Catalysis. The author of the article were Lu, Jia-Ming; Huo, Yong-Wang; Qi, Xinxin; Wu, Xiao-Feng. The article conveys some information:
A palladium-catalyzed reductive carbonylation reaction has been developed for the synthesis of quinazolines I (R = Ph, 3-fluorophenyl, 4-methylphenyl, naphthalen-2-yl, etc.; R1 = H, Me, F, Cl; R2 = H, Me, F). With N-(2-iodophenyl)benzimidamides 2-I-3-R14-R2-C6H2NHC(=NH)R as starting materials, a series of quinazolines I were obtained through the aromatic aldehyde intermediates in moderate to good yields with good functional group compatibilities. In this system, silane act as better nucleophile than amidine. The experimental part of the paper was very detailed, including the reaction process of 4-Chloro-2-iodoaniline(cas: 63069-48-7SDS of cas: 63069-48-7)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.SDS of cas: 63069-48-7
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com