COA of Formula: C5H4INIn 2022 ,《Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications》 was published in Nature Communications. The article was written by Xu, Yuling; Li, Chonglu; Lu, Shuai; Wang, Zhizheng; Liu, Shuang; Yu, Xiujun; Li, Xiaopeng; Sun, Yao. The article contains the following contents:
Although Ru(II)-based agents are expected to be promising candidates for substituting Pt-drug, their in vivo biomedical applications are still limited by the short excitation/emission wavelengths and unsatisfactory therapeutic efficiency. Herein, we rationally design a Ru(II) metallacycle with excitation at 808 nm and emission over 1000 nm, namely Ru1085, which holds deep optical penetration (up to 6 mm) and enhanced chemo-phototherapy activity. In vitro studies indicate that Ru1085 exhibits prominent cell uptake and desirable anticancer capability against various cancer cell lines, especially for cisplatin-resistant A549 cells. Further studies reveal Ru1085 induces mitochondria-mediated apoptosis along with S and G2/M phase cell cycle arrest. Finally, Ru1085 shows precise NIR-II fluorescence imaging guided and long-term monitored chemo-phototherapy against A549 tumor with minimal side effects. We envision that the design of long-wavelength emissive metallacycle will offer emerging opportunities of metal-based agents for in vivo biomedical applications. In the part of experimental materials, we found many familiar compounds, such as 4-Iodopyridine(cas: 15854-87-2COA of Formula: C5H4IN)
4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.COA of Formula: C5H4IN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com