Wang, Shan; Zhang, Jian-Xin; Zhang, Tian-Yi; Meng, Huan; Chen, Bi-Hong; Shu, Wei published their research in Nature Communications in 2021. The article was titled 《Enantioselective access to chiral aliphatic amines and alcohols via Ni-catalyzed hydroalkylations》.Category: iodides-buliding-blocks The article contains the following contents:
A nickel-catalyzed enantioselective hydroalkylation of acyl enamines R1C(O)N(R2)CH=CH2 (R1 = C6H5, 1-naphthyl, 2-furyl, etc.; R2 = H, Me) and enol esters R3C(O)OCH=CH2R4 (R3 = C6H5, 4-CH3OC6H4, 2-naphthyl; R4 = H, C4H9, C6H13, (CH2)4Cl) with alkyl halides R5I [R5 = 2-phenylethyl, 3-(thiophen-2-yl)propyl, 3-(9H-carbazol-9-yl)propyl, etc.] to afford enantioenriched α-branched aliphatic acyl amines (R)-R1C(O)N(R2)CH(R5)Me and esters R3C(O)OCH(R5)CH2R4 in good yields with excellent levels of enantioselectivity has been described. The operationally simple protocol provides a straightforward access to chiral secondary alkyl-substituted amine and secondary alkyl-substituted alc. derivatives from simple starting materials with great functional group tolerance. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Category: iodides-buliding-blocks)
tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Category: iodides-buliding-blocks
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com