In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6940-76-7, name is 1-Chloro-3-iodopropane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 1-Chloro-3-iodopropane
335 mg (1.30 mmol) of 4-(3,4-difluorophenyl)phthalazin-1(2H)-one (8n) was dissolved in 10 ml of N,N-dimethylformamide, and 62 mg (1.56 mmol) of sodium hydride were added at 0oC. After being stirred for 30 min, 0.21 ml (1.95 mmol) 3-iodo-1-chloropropane was then added to reaction mixture. After being stirred for 1 h, the reaction mixture was combined with 50 ml of water and extracted with ethylacetate (50 ml X 2) being washed with water and a sodium hydroxide solution, and then the combined organic layer was dried over anhydrous sodium sulfate, and filtered. The solvent was removed from the filtrate under a reduced pressure, and the resulting residue was refined by silica gel column chromatography (ethyl acetate : n-hexane = 1 : 3) to obtain 400 mg (yield 92%) of the title compound.
The synthetic route of 6940-76-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lim, Chae Jo; Kim, Soo Hee; Lee, Byung Ho; Oh, Kwang-Seok; Yi, Kyu Yang; Bioorganic and Medicinal Chemistry Letters; vol. 22; 1; (2012); p. 427 – 430;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com