In 2022,Gentili, Valentina; Turrin, Giulia; Marchetti, Paolo; Rizzo, Sabrina; Schiuma, Giovanna; Beltrami, Silvia; Cristofori, Virginia; Illuminati, Davide; Compagnin, Greta; Trapella, Claudio; Rizzo, Roberta; Bortolotti, Daria; Fantinati, Anna published an article in Bioorganic Chemistry. The title of the article was 《Synthesis and biological evaluation of novel rhodanine-based structures with antiviral activity towards HHV-6 virus》.Related Products of 626-02-8 The author mentioned the following in the article:
An increased awareness of diseases associated with Human herpesvirus 6 (HHV-6) infection or reactivation has resulted in a growing interest in the evaluation of the best treatment options available for the clin. management of HHV-6 disease. However, no compound has yet been approved exclusively for HHV-6 infection treatment. For this reason, the identification of anti-HHV6 compounds provides a valuable opportunity for developing efficient antiviral therapies. A possible target for antiviral drugs is the virus-cell fusion step. In this study, we synthesized potential fusion intermediates inhibitors based on the rhodanine structure. The obtained derivatives were tested for cytotoxicity and for antiviral activity in human cells infected with HHV6. Level of infection was monitored by viral DNA quantification at different time points up to 7 days post infection. Among the synthesized derivatives, 9e showed a significative inhibitory effect on viral replication that lasted over 7 days, probably attributable to the particular combination of hydrophilic and hydrophobic substituents to the rhodanine moiety. Our results support the use of these amphipathic fusion inhibitors for the treatment of HHV-6 infections. In the experiment, the researchers used 3-Iodophenol(cas: 626-02-8Related Products of 626-02-8)
3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Related Products of 626-02-8
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com