Some common heterocyclic compound, 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, molecular formula is C6H3BrINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H3BrINO2
Under the protection of argon, 1-naphthalene boronic acid (22.0 g, 128.1 mmol), 4-bromo-1-iodo-2-nitrobenzene (35.0 g, 106.8 mmol) and Na2CO3 (34.0 g, were sequentially added to the reaction flask. 320.4 mmol), tetrakistriphenylphosphine palladium (6.17 g, 5.3 mmol), toluene (640 ml) and ethanol (160 ml), and the mixture was stirred at 90 C for 3 hours. After the stirring was completed, distilled water (160 ml) was poured, and the mixture was cooled to room temperature, the organic phase was extracted with ethyl acetate, and the organic phase was concentrated to give compound B1 (30 g, 86%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 112671-42-8, its application will become more common.
Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Zhou Wenting; Cai Hui; (39 pag.)CN108822020; (2018); A;,
Iodide – Wikipedia,
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