Application of 82998-57-0,Some common heterocyclic compound, 82998-57-0, name is 3-Iodo-4-methylbenzoic acid, molecular formula is C8H7IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-iodo-4-methylbenzoic acid (3.2 g, 12.2 mmol) was dispersed in 50 mL of thionyl chloride.The reaction system was heated to 82 C, kept under reflux for 1 hour, and cooled to room temperature.The reaction solution was added to 50 mL of toluene while maintaining slow stirring.Concentrate under reduced pressure to a pale yellow oil.After the concentrate was dissolved in 100 mL of dichloromethane,To this solution was added 3-trifluoromethylaniline (2.3 mL, 18.3 mmol) and diisopropylethylamine (9 mL).The reaction system was stirred at room temperature overnight to precipitate a large amount of white solid.The reaction solution was concentrated under reduced pressure and then evaporated.Washed with saturated ammonium chloride solution and saturated brine,The organic phase was dried over anhydrous magnesium sulfate and concentrated.Purification by silica gel column chromatography to obtain compound 8(3.5 g, 71%) was obtained as a white solid.
The synthetic route of 82998-57-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shenzhen Ruixi Biological Technology Co., Ltd.; Jiao Zhaodong; Li Xitao; Tao Guanyu; Pan Zhengying; (36 pag.)CN109305944; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com