Li, Xuemin; Zhang, Beibei; Zhang, Jingran; Wang, Xi; Zhang, Dongke; Du, Yunfei; Zhao, Kang published an article in 2021. The article was titled 《Synthesis of 3-Methylthioindoles via Intramolecular Cyclization of 2-Alkynylanilines Mediated by DMSO/DMSO-d6 and SOCl2》, and you may find the article in Chinese Journal of Chemistry.Reference of 4-Chloro-2-iodoaniline The information in the text is summarized as follows:
The intramol. cyclization of 2-alkynylanilines mediated by DMSO/SOCl2 was found to afford biol. interesting 3-methylthioindoles, which were rarely obtained by the exiting methods. DMSO could also be replaced with its deuterated counterpart, enabling the method applicable to the construction of indole skeleton bearing a SCD3 moiety at its 3-position. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7Reference of 4-Chloro-2-iodoaniline)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Reference of 4-Chloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com