In 2022,Hess, A.; Guelen, H. C.; Alandini, N.; Mourati, A.; Guersoy, Y. C.; Knochel, P. published an article in Chemistry – A European Journal. The title of the article was 《Preparation of Polyfunctionalized Aromatic Nitriles from Aryl Oxazolines》.Category: iodides-buliding-blocks The author mentioned the following in the article:
A selective ortho,ortho’-functionalization of readily available aryl oxazolines by two successive magnesiations with sBu2Mg in toluene followed by trapping reactions with electrophiles, such as (hetero)aryl iodides or bromides, iodine, tosyl cyanide, Et cyanoformate or allylic bromides (39 examples, 62-99% yield) was reported. Treatment of these aryl oxazolines with excess oxalyl chloride and catalytic amounts of DMF (50°C, 4 h) provided the corresponding nitriles I [R = H, 3-F, 4-OMe, etc.; R1 = I, CN, 3-MeC6H4, etc.; R2 = H, 2-thienyl, 1-naphthyl, etc.] (36 examples, 73-99% yield). After reading the article, we found that the author used 4-Iodopyridine(cas: 15854-87-2Category: iodides-buliding-blocks)
4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Category: iodides-buliding-blocks
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com