In 2022,Wessig, Pablo; Badetko, Dominik; Czarnecki, Maciej; Wichterich, Lukas; Schmidt, Peter; Brudy, Cosima; Sperlich, Eric; Kelling, Alexandra published an article in Journal of Organic Chemistry. The title of the article was 《Studies toward the Total Synthesis of Arylnaphthalene Lignans via a Photo-Dehydro-Diels-Alder (PDDA) Reaction》.COA of Formula: C6H5IO The author mentioned the following in the article:
An efficient method for the preparation of arylnaphthalene lignans (ANLs) was developed, which is based on the photo-dehydro-Diels-Alder (PDDA) reaction. While intermol. PDDA reactions turned out to be inefficient, the intramol. variant using suberic acid as tether linking two aryl propiolic esters smoothly provided naphthalenophanes. The irradiations were performed with a previously developed annular continuous-flow reactor and UVB lamps. In this way, the natural products Alashinol D, Taiwanin C, and an unnamed ANL could be prepared In addition to this study using 3-Iodophenol, there are many other studies that have used 3-Iodophenol(cas: 626-02-8COA of Formula: C6H5IO) was used in this study.
3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.COA of Formula: C6H5IO
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com