《Synthesis of antisense oligonucleotides containing acyclic alkynyl nucleoside analogs and their biophysical and biological properties》 was written by Ogata, Aya; Maeda, Yusuke; Ueno, Yoshihito. Application In Synthesis of 2-Amino-5-iodopyrimidin-4(1H)-one And the article was included in Bioorganic & Medicinal Chemistry on April 1 ,2017. The article conveys some information:
The synthesis of oligonucleotide (ON) analogs, which can be used as antisense mols., has recently gained much attention. Here, we report the synthesis and properties of an ON analog containing acyclic thymidine and cytidine analogs with a 4-pentyl-1,2-diol instead of the D-ribofuranose moiety. The incorporation of these analogs into the ON improved its nuclease resistance to 3′-exonucleases. Furthermore, it was found that the incorporation of the acyclic thymidine analog into a DNA/RNA duplex accelerates the RNA cleavage of a DNA/RNA duplex by Escherichia coli RNase H. In the part of experimental materials, we found many familiar compounds, such as 2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1Application In Synthesis of 2-Amino-5-iodopyrimidin-4(1H)-one)
2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Application In Synthesis of 2-Amino-5-iodopyrimidin-4(1H)-one
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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com