《A Mild and Versatile Friedel-Crafts Methodology for the Diversity-Oriented Synthesis of Redox-Active 3-Benzoylmenadiones with Tunable Redox Potentials》 was published in Chemistry – A European Journal in 2020. These research results belong to Cotos, Leandro; Donzel, Maxime; Elhabiri, Mourad; Davioud-Charvet, Elisabeth. COA of Formula: C7H5IO2 The article mentions the following:
A series of highly diversified 3-aroylmenadiones I [R = 4-F, 4-CF3, 3-NO2, etc.] was prepared by a new Friedel-Crafts acylation variant/oxidative demethylation strategy. A mild and versatile acylation was performed between 1,4-dimethoxy-2-methylnaphthalene and various activated/deactivated benzoic and heteroaromatic carboxylic acids, in the presence of mixed trifluoroacetic anhydride and triflic acid, at room temperature and in air. The 1,4-dimethoxy-2-methylnaphthalene-derived benzophenones II were isolated in high yield, and submitted to oxidative demethylation with cerium ammonium nitrate to produce 3-aroylmenadiones I. All 1,4-naphthoquinone derivatives were investigated as redox-active electrophores by cyclic voltammetry. The electrochem. data recorded for 3-acylated menadiones were characterized by a second redox process, the potentials of which cover a wide range of values (500 mV). These data emphasize the ability of the generated structural diversity at the 3-aroyl chain of these electrophores to fine-tune their corresponding redox potentials. These properties were of significance in the context of antimalarial drug development and understanding of the mechanism of bioactivation/action. The experimental part of the paper was very detailed, including the reaction process of 4-Iodobenzoic acid(cas: 619-58-9COA of Formula: C7H5IO2)
4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.COA of Formula: C7H5IO2Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com