Thanetchaiyakup, Adisak; Borwornpinyo, Suparerk; Rattanarat, Hassayaporn; Kanjanasirirat, Phongthon; Jearawuttanakul, Kedchin; Seemakhan, Sawinee; Chuanopparat, Nutthawat; Ngernmeesri, Paiboon published an article in 2021. The article was titled 《Copper-catalyzed synthesis and anticancer activity evaluation of indolo[1,2-a]quinoline derivatives》, and you may find the article in Tetrahedron Letters.Application of 15164-44-0 The information in the text is summarized as follows:
A simple and effective one-pot synthesis of substituted indolo[1,2-a]quinolines I (R = CHO, CN; R1 = H, Me, Cl, F, etc.; R2 = H, Me, Ph) has been developed. The desired products I were obtained in up to 98% yield when substituted 2-methyindoles II were treated with 2-iodobenzaldehyde in the presence of Cs2CO3, CuI and L-proline. The mechanistic study confirmed that the reaction sequence involved an intermol. Knoevenagel reaction followed by an intramol. Ullmann-type coupling reaction. Moreover, some of the synthesized compounds I were found to be active against human breast (MCF-7) and colorectal (HCT-116) cancer cells with IC50 values of 27.96μM and in the range of 6.21-46.91μM, resp. In the experimental materials used by the author, we found 4-Iodobenzaldehyde(cas: 15164-44-0Application of 15164-44-0)
4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Application of 15164-44-0
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com