Zhong, Xianqiang; Luo, Jianghao; Zhou, Wei; Cai, Qian published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《A Synthesis of Spirooxindole-Isoindolinones Through Ugi Reaction Followed by Copper-Catalyzed Tandem C-N/C-C Coupling Process》.Safety of 2-Iodobenzoic acid The article contains the following contents:
A synthesis of spiroindolinone-isoindolinone skeletons was presented. The protocol was through a Ugi four-component reaction followed by highly efficient and mild copper-catalyzed intramol. tandem C-N/C-C coupling process. Control experiments demonstrated that the formation of C-C bond was a copper catalyzed coupling process rather than base promoted nucleophilic aromatic substitution pathway which proposed in Prof. Van der Eycken’s palladium catalyst system previously. In the part of experimental materials, we found many familiar compounds, such as 2-Iodobenzoic acid(cas: 88-67-5Safety of 2-Iodobenzoic acid)
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Safety of 2-Iodobenzoic acid
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com