In 2022,Zhang, Haoxiang; Liang, Mengze; Zhang, Xiao; He, Meng-Ke; Yang, Chao; Guo, Lin; Xia, Wujiong published an article in Organic Chemistry Frontiers. The title of the article was 《Electrochemical synthesis of functionalized gem-difluoroalkenes with diverse alkyl sources via a defluorinative alkylation process》.Application of 301673-14-3 The author mentioned the following in the article:
An electrochem. defluorinative alkylation protocol of α-trifluoromethyl alkenes was described. This reaction enabled the preparation of functionalized gem-difluoroalkenes F2C=C(R)CH2R1 [R = 4-MeC6H4, 4-MeOC6H4, 2-naphthyl, etc.; R1 = cyclohexyl, tetrahydropyran-4-yl, Bn, etc.] with the use of diverse alkyl sources including organohalides, N-hydroxyphthalimide (NHP) esters and Katritzky salts. This method exhibited lots of synthetic advantages including mild conditions, simple operation, and convenience of amplification, and provides a new route for the synthesis of gem-difluoroalkenes. In the experimental materials used by the author, we found tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Application of 301673-14-3)
tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application of 301673-14-3
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com