In 2022,Stivanin, Mateus L.; Gallo, Rafael D. C.; Spadeto, Joao Paulo M.; Cormanich, Rodrigo A.; Jurberg, Igor D. published an article in Organic Chemistry Frontiers. The title of the article was 《A visible light-mediated three-component strategy based on the ring-opening of cyclic ethers with aryldiazoacetates and nucleophiles》.COA of Formula: C7H5IO2 The author mentioned the following in the article:
A blue light-promoted reaction between aryldiazoacetates 4-R1C6H4C(=N2)C(O)2R2 (R1 = F, Cl, CF3, etc.; R2 = Me, t-Bu, Bn, propargyl) and different nucleophiles, e.g., benzoic acid has been developed in the presence of THF (and other cyclic ethers like THP, 1,4-dioxane, and 1,4,7,10,13,16-hexaoxacyclooctadecane) as the solvent, allowing the incorporation of these three elements into a single products, e.g., I. Formally, this transformation represents an O-H insertion strategy of more complex alcs. into aryldiazoesters without the need of pre-assembling them. The method is mild and efficient and proceeds in the absence of metals, generally at room temperature After reading the article, we found that the author used 2-Iodobenzoic acid(cas: 88-67-5COA of Formula: C7H5IO2)
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.COA of Formula: C7H5IO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com