Related Products of 619-58-9In 2019 ,《A Solution Phase Platform to Characterize Chemical Reaction Compatibility with DNA-Encoded Chemical Library Synthesis》 was published in ACS Combinatorial Science. The article was written by Ratnayake, Anokha S.; Flanagan, Mark E.; Foley, Timothy L.; Smith, Justin D.; Johnson, Jillian G.; Bellenger, Justin; Montgomery, Justin I.; Paegel, Brian M.. The article contains the following contents:
DNA-encoded chem. library (DECL) synthesis must occur in aqueous media under conditions that preserve the integrity of the DNA encoding tag. While the identification of “”DNA-compatible”” reaction conditions is critical for the development of DECL designs that explore previously inaccessible chem. space, reports measuring such compatibility have been largely restricted to methods that do not faithfully capture the impact of reaction conditions on DNA fidelity in solution phase. Here we report a comprehensive methodol. that uses soluble DNA substrates that exactly recapitulate DNA’s exposure to the chem. reactive species of DECL synthesis. This approach includes the assessment of chem. fidelity (reaction yield and purity), encoding fidelity (ligation efficiency), and readability (DNA compatibility), revealing the fate of the DNA tag during DECL chem. from a single platform. The results came from multiple reactions, including the reaction of 4-Iodobenzoic acid(cas: 619-58-9Related Products of 619-58-9)
4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Related Products of 619-58-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com