COA of Formula: C4H4IN3OOn May 7, 2005 ,《Synthesis and triplex forming properties of pyrrolidino pseudoisocytidine containing oligodeoxynucleotides》 appeared in Organic & Biomolecular Chemistry. The author of the article were Mayer, Alain; Haeberli, Adrian; Leumann, Christian J.. The article conveys some information:
Pyrrolidino pseudo-C-nucleosides are isosteres of natural deoxynucleosides which are protonated at the pyrrolidino ring nitrogen under physiol. conditions. As constituents of a triplex forming oligodeoxynucleotide (TFO), the pos. charge is expected to stabilize DNA triple helixes via electrostatic interactions with the phosphodiester backbone of the target DNA. We describe the synthesis of the pyrrolidino iso-cytidine pseudo-nucleoside and the corresponding phosphoramidite building block and its incorporation into TFOs. Such TFOs show substantially increased DNA affinity compared to unmodified oligodeoxynucleotides. The increase in affinity is shown to be due to the pos. charge at the pyrrolidino subunit. After reading the article, we found that the author used 2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1COA of Formula: C4H4IN3O)
2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.COA of Formula: C4H4IN3O
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com