《Novel D-π-A type near-infrared fluorescent probes for the detection of Aβ40 aggregates》 was written by Lv, Guanglei; Xu, Yunze; Yang, Jiajia; Li, Wenhui; Li, Chunxia; Sun, Anyang. Synthetic Route of C7H5IO And the article was included in Analyst (Cambridge, United Kingdom) in 2020. The article conveys some information:
Aberrant accumulation of Amyloid-β (Aβ) peptide is closely related to Alzheimer′s disease. Thus, it is important to develop featured probes for the specific detection of Aβ species. Herein, the authors designed and synthesized a novel near-IR fluorescent probe SDPY based on the D-π-A architecture for the detection of Aβ aggregates. The probe SDPY displayed higher affinity for Aβ40 aggregates over Aβ42 aggregates in solution (Kd = 164 nM vs. 2.1 μM). In addition, SDPY showed excellent anti-interference against a wide range of other substances. Furthermore, SDPY was capable of labeling Aβ40 aggregates better than Aβ42 aggregates in the brain sections of AD transgenic mouse models.4-Iodobenzaldehyde(cas: 15164-44-0Synthetic Route of C7H5IO) was used in this study.
4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Synthetic Route of C7H5IO
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com