《Ex vivo model for elucidating the functional and structural differentiation of the embryonic mouse thyroid》 was written by Carre, Aurore; Gawade, Sanjay; Dertschnig, Simone; Hafen, Kathrin; Polak, Michel; Szinnai, Gabor. Related Products of 516-12-1This research focused onTSH embryonic follicular cell differentiation parathyroid; Culture model; Development; Differentiation; Thyroid. The article conveys some information:
Terminal thyroid gland differentiation – the last developmental step needed to enable thyroid hormone (T4) synthesis – involves profound structural and biochem. changes in the thyroid follicular cells (TFCs). We aimed to develop an ex vivo thyroid model of embryonic mouse thyroid that would replicate the in vivo TFC differentiation program. E13.5 thyroid explants were cultured ex vivo in chem. defined medium for 7 days. Immunostaining and qPCR of thyroid explants showed thyroglobulin production onset, follicle formation, and T4 synthesis onset in 1-, 3-, and 5-day-old cultures, resp. Differentiation was maintained and follicular growth continued throughout the 7-day culture period. Pharmacol. approaches to culture inhibition were performed successfully in the ex vivo thyroids. Our robust and well described ex vivo thyroid culture model replicates the sequence of thyroid differentiation to T4 synthesis seen in vivo. This model can be used to test the effects of pharmacol. inhibitors on thyroid hormone production The experimental process involved the reaction of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Related Products of 516-12-1)
1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Related Products of 516-12-1
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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com