In 2022,Cai, Chen; Lu, Yi; Yuan, Chengcheng; Fang, Zheng; Yang, Xiaobing; Liu, Chengkou; Guo, Kai published an article in ACS Sustainable Chemistry & Engineering. The title of the article was 《Metal-Free C-C Cross Coupling: Electrosynthesis of Azaheterocycles through Anodic Oxidation Cyclization of 1,6-Enynes》.Application In Synthesis of 4-Chloro-2-iodoaniline The author mentioned the following in the article:
A straightforward synthesis of azaheterocycles has been developed through electrochem. aerobic oxidation cyclization using a user-friendly undivided electrolytic cell at room temperature under catalyst-free conditions. This green and practical electrosynthesis strategy features good functional group, diverse electronic and steric properties tolerance. Based on a series of mechanistic investigation, including isotope labeling, singlet oxygen inhibiting, superoxide radical anion inhibiting, radical-trapping, cyclic voltammetry and controlled potential electrolysis experiments, a possible N-centered radical-initiated mechanism was proposed. The experimental process involved the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Application In Synthesis of 4-Chloro-2-iodoaniline)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Application In Synthesis of 4-Chloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com