Reference of 20555-91-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 16 (3R,4S)-4-(3′,4′-Dichlorobiphenyl-4-yloxy)-1-pyridin-3-yl-pentan-3-ol, oxalic acid salt Prepared according to the method described in Example 12b) from (1S,2R)-4-[2-(tert-butyldimethylsilanyloxy)-1-methyl-4-pyridin-3-ylbutoxy]benzeneboronic acid (0.20 g, Example 11)), 3,4-dichloriodobenzene (0.273 g), 2M aqueous sodium carbonate (0.5 ml) and tetrakis(triphenylphosphine)palladium (0) (0.025 g) in toluene (5 ml) and ethanol (1 ml). The reaction mixture was heated at 100 C. for 4 hours. After cooling, the solution was concentrated under reduced pressure. Concentrated hydrochloric acid (1 ml) was added to a solution of the residue in 4:1 methanol:water (5 ml) and the suspension was stirred at room temperature for 3 hours. After work up, the residue was purified by normal-phase HPLC eluding with a gradient of 0-25% ethanol in dichloromethane to give a gum, of which the oxalate salt was made (0.23 g). m.p. 86.4-88.4 C. MS (APCI) 402/404 (M+H)+(free base) 1H NMR (DMSO) 8.51(1H, d); 8.46(1H, dd); 7.62(1H, d); 7.55(1H, dt); 7.48-7.45(3H, m); 7.36(1H, dd); 7.23(1H, dd); 6.93(2H,d); 4.39(1H, dq); 3.87-3.85(1H, m); 2.95-2.91(1H, m); 2.76-2.77(1H, m); 2.21(1H, br.s); 1.89-1.84(2H, m); 1.30(3H, d).
The chemical industry reduces the impact on the environment during synthesis 1,2-Dichloro-4-iodobenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; AstraZeneca AB; US6300352; (2001); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com