《Pd(II)-Catalyzed Enantioselective γ-C(sp3)-H Functionalizations of Free Cyclopropylmethylamines》 was written by Zhuang, Zhe; Yu, Jin-Quan. Formula: C7H7I And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:
Herein, the Pd-catalyzed enantioselective C(sp3)-H functionalization of free aliphatic amines (cyclopropylmethylamines) enabled by a chiral bidentate thioether ligand was reported. This ligand’s privileged bidentate coordination mode and thioether motif favor the generation of the requisite mono(amine)-Pd(II) intermediate, thus enabling the enantioselective C-H activation of free amines. The resulting C-Pd(II) species could engage in either Pd(II)/Pd(IV) or Pd(II)/Pd(0) catalytic cycles, enabling access to a diverse range of products I [R1 = n-pentyl, 2,6-di-FC6H3, Bn, etc.; R2 = H, Boc, Bz; Ar = Ph, 4-MeC6H4, 4-pyridyl, etc.], II [R1 = H, Bn; R2 = H, 2,6,-di-FC6H3, 2,6,-di-ClC6H3, 2,6,-di-MeC6H3, (CH2)3C6H5] and III [R1 = H, CH2CH2CH(Me)2; R2 = Boc, 2,6,-di-FC6H3, 2,6,-di-ClC6H3, 2,6,-di-MeC6H3] through (hetero)arylation, carbonylation and olefination reactions. Consequently, this versatile reactivity offered medicinal chemists a general strategy to rapidly prepare and functionalize biol. relevant amines. In the experiment, the researchers used 1-Iodo-4-methylbenzene(cas: 624-31-7Formula: C7H7I)
1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Formula: C7H7I
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com