In 2022,Kotipalli, Ramesh; Nagireddy, Attunuri; Reddy, Maddi Sridhar published an article in Organic & Biomolecular Chemistry. The title of the article was 《Palladium-catalyzed cyclizative cross coupling of ynone oximes with 2-haloaryl N-acrylamides for isoxazolyl indoline bis-heterocycles》.COA of Formula: C6H5ClIN The author mentioned the following in the article:
Herein, a dual-cyclizative coupling of ynone oxime ethers RC(=NOR1)CCR2 (R = Ph, furan-2-yl, 3,4,5-trimethoxyphenyl, etc.; R1 = Me, Bn; R2 = Ph, 6-methoxynaphthalen-2-yl, cyclohex-1-en-1-yl, phenanthren-9-yl, etc.) with acrylamides R3N(R4)C(O)C(CH2)R5 (R3 = 2-iodophenyl, 5-fluoro-2-iodophenyl, 2-bromophenyl, etc.; R4 = Me, Et; R5 = H, Me) for the synthesis of methylene-linked isoxazolyl 2-oxindoles I (R6 = H, 5-Et, 6-F, 5-Cl, etc.) was demonstrated. The cascade was triggered by a palladium(II)-catalyzed ynone oxime ether cyclization, which underwent a Heck-type coupling intercepted by an aryl iodide insertion. Control experiments were carried out to understand the mechanism. In the experimental materials used by the author, we found 4-Chloro-2-iodoaniline(cas: 63069-48-7COA of Formula: C6H5ClIN)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).COA of Formula: C6H5ClIN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com