In 2015,Mahamulkar, Shraddha G.; Cisarova, Ivana; Jahn, Ullrich published 《The Lithiation Reactivity and Selectivity of Differentially Branched Alkyldiphenylphosphine Oxides – A Simple and Versatile Approach to ortho-Functionalized Arylphosphine Oxides》.Advanced Synthesis & Catalysis published the findings.Synthetic Route of C2H4I2 The information in the text is summarized as follows:
Alkyldiphenylphosphine oxides typically undergo α-deprotonation with alkyllithium reagents. Here, the lithiation of differentially branched alkyldiphenylphosphine oxides was investigated and a diverse, but predictable reactivity was found. γ-Branched derivatives undergo selective directed ortho-metalation (DoM) using butyllithium and TMEDA as an additive. With decreasing degree of γ-branching α-lithiation becomes predominant. The ortho-phosphinoyllithium intermediates are subject to functionalization and C-C bond forming reactions, thus providing a convenient approach to new phosphine oxides and phosphine-borane complexes, which have a good potential for an approach to new ligands for catalysis. The results came from multiple reactions, including the reaction of 1,2-Diiodoethane(cas: 624-73-7Synthetic Route of C2H4I2)
1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Synthetic Route of C2H4I2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com