In 2022,Zhang, Xing Xing; Diao, Liang Zhuo; Chen, Liu Zeng; Ma, Duo; Wang, Yu Meng; Jiang, Han; Ruan, Ban Feng; Liu, Xin Hua published an article in European Journal of Medicinal Chemistry. The title of the article was 《Discovery of 4-((E)-3,5-dimethoxy-2-((E)-2-nitrovinyl)styryl)aniline derivatives as potent and orally active NLRP3 inflammasome inhibitors for colitis》.Safety of 4-Iodobenzoic acid The author mentioned the following in the article:
A series of pterostilbene derivatives I [R1 = tert-Bu, Ph, 2-furyl, etc] were designed and synthesized based on previous SAR, leading to discovery of new effective NLRP3 inflammasome inhibitors with metabolic stability. Among them, the most effective compound I [R1 = 2-furyl] showed high inhibitory efficacy (against IL-1 β: IC50 = 1.23μM) and almost no toxicity (against IL-1 b: IC50 > 100μM). Further mechanism studies have showed that compound I [R1 = 2-furyl] directly targets the NLRP3 and affects the assembly of inflammasomes to inhibit the activation of NLRP3 inflammasomes. More importantly, in vitro experiments show that compound I [R1 = 2-furyl] has a significant therapeutic effect on DSS-induced colitis in mice with good metabolic stability to liver microsomes (t1/2 = 138.6 min). This research encourages the further development of more effective NLRP3 inflammasome inhibitors based on this chem. scaffold. In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Safety of 4-Iodobenzoic acid) was used in this study.
4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Safety of 4-Iodobenzoic acid
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com