Adding a certain compound to certain chemical reactions, such as: 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63262-06-6, HPLC of Formula: C6H2Br2I2
To a 100 ml Schlenk reaction vessel were added under a nitrogen atmosphere 4.39 g (9.00 mmol) of 1,4-dibromo-2,5-diiodobenzene (compound of the formula (5)) synthesized in Synthetic Example 1, 974 mg (0.84 mmol) of tetrakis(triphenylphosphine)palladium (manufactured by Tokyo Chemical Industry Co. Ltd.) as a catalyst, and 4.16 g (20.7 mmol) of 2-bromophenylboronic acid (manufactured by Sigma-Aldrich) (compound of the formulae (6) and (7)). Further, 72 ml of toluene, 18 ml of ethanol, and an aqueous solution composed of 5.72 g (54.0 mmol) of sodium carbonate and 22 ml of water were added. The whole was immersed in an oil bath at 85C and stirred for 15 hours. After cooling to room temperature, dichloromethane and a saturated aqueous sodium chloride solution were added and phase separation was conducted. The organic phase was concentrated under reduced pressure. The residue was recrystallized from toluene to obtain white needle-like crystals (3.68 g, yield 75%). Melting point: 230-231C. 1H-NMR (CDCl3, 21C): delta=7.70 (d, J=8.0Hz, 2H), 7.55 (d, J=1.5Hz, 2H), 7.45-7.23 (m, 6H). MS m/z: 546 (M+, 92%), 466 (M+-Br, 45), 386 (M+-2Br, 53), 226 (M+-4Br, 100).
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Reference:
Patent; Tosoh Corporation; EP2067782; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com